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Fentanyl is a synthetic opioid that is 80-100 times stronger than morphine. Pharmaceutical fentanyl was developed for the pain management treatment of cancer patients however applied in a patch on the skin. Many users believe that they are purchasing heroin and actually don’t know that they are purchasing fentanyl – which often results in overdose deaths. Clandestinely-produced fentanyl is primarily manufactured in Mexico
Fentanyl (Transdermal Duragesic) is indicated for the management of persistent, moderate to severe chronic pain that:
-Requires continuous, around-the-clock opioid administration for an extended period of time, and
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Fentanyl transdermal patch (25mg/hour) provides an effective treatment for cancer pain. Fentanyl belongs to a class of drugs called opioid agonists. A class of drugs is a group of medications that work similarly. These drugs are often used to treat similar conditions. Fentanyl works in your brain to change how your body feels and responds to pain. However, Transdermal fentanyl patches for sale, Buy Fentanyl Transdermal Patch or Fentanyl(Transdermal) Patch for sale and Fentanyl Patch for sale.
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This means you may need to use it with other medications. These are people who have taken another opioid pain drug that no longer works as well. However, fentanyl has high abuse potential, and transdermal patches may be misused for their euphoric effects. Fentanyl is a very potent opioid and can cause a fatal overdose. Being aware of the risks of using a fentanyl patch can help to prevent an overdose or addiction. Your doctor may start you on a low-dose fentanyl patch and gradually increase your dose, not more often than once every 3 days at first, and then not more often than once every 6 days.
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Dosage and Administration of fentanyl (opioid)
Administration steps of Fentanyl Patch
Choose a suitable site such as a dry, flat surface of non-irradiated and non-irritated skin for patch application. Commonly used sites include the chest and upper arm. Gently cleansing with clean water. Avoid using any soap or alcohol as these may result in skin irritation. Clipping off any hair if present, with scissors. Avoid using a shaver as this may result in skin irritation. Tear along the pre-cut edge to remove the patch. To avoid accidentally cutting the patch, do not use scissors to cut open the packet. Peel off one side of the plastic backing first, taking care not to touch the adhesive. Apply the adhesive to the application site. Ensure that there are no air bubbles present.
Press the patch firmly in place with the palm of your hand and hold for about 30 seconds to ensure good adherence to the skin. If adhesion of the patch to the skin is a problem, use an adhesive film dressing over the patch. Remove the patch after 72 hours and apply a new patch to a different area of the skin.
Dosage and Administration / Dosage Forms & Strengths
Transdermal patch: 12mcg/hour, 25mcg/hour, 37.5 mcg/hour, 50mcg/hour, 75mcg/hour and 100mcg/hour.
Transdermal fentanyl comes as a patch to apply to the skin. Change your patch at about the same time of day every time you change it.
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and
misuse. Mild to moderate hepatic and renal impairment: Initiate treatment with one-half the usual starting dose.
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Side Effects (is fentanyl an opioid)
Fentanyl patches may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Nausea, fatigue, confusion, vomiting, constipation, Constricted pupils, light-headedness, dizziness, trouble concentrating, drowsiness, or headache may occur sometimes, Mild irritation also, Sweating or itching and swelling of the face, upper stomach pain, throat, or tongue, bloating or swelling of the face, arms, hands, lower legs, or feet, tremor, unusual weight gain or loss or redness at the application site may also occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Headache, mood changes, feeling cold, drowsiness, depression, difficulty falling asleep or staying asleep
uncontrollable shaking of a part of the body, pain, burning, tingling, or numbness in the hands or feet,
Dry mouth or constipation also, stomach pain, nausea, indigestion, back pain, difficulty urinating, itching, skin irritation or redness sleepiness and itching, or swelling in the area where you wore the patch.
-In patients who are not opioid-tolerant.
-In the management of acute pain or in patients who require opioid analgesia for a
short period of time.
-In the management of post-operative pain, including use after outpatient or day
surgeries (e.g., tonsillectomies).
-In the management of mild pain.
-In the management of intermittent pain [e.g. use on an as-needed basis (PRN)].
Do not use this medication if you:
-are allergic to fentanyl, the adhesives used in the patch, or any ingredients of the medication
-are not already using opioid (narcotic) painkillers to manage your pain
-Also, have acute or severe bronchial asthma and,
-are pregnant, in labour or delivering, or breastfeeding.
WARNINGS AND PRECAUTIONS
Fentanyl can slow or stop your breathing, and may be habit-forming. Misuse of Fentanyl or overdose may cause OR Death, especially in a child or other person using the medicine without a prescription. Using this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Since the peak fentanyl levels occur between 24 and 72 hours of treatment, prescribers should be aware that serious or life-threatening hypoventilation may occur, even in opioid-tolerant patients, during the initial application period. However, Transdermal fentanyl patches are for sale, Buy Fentanyl Transdermal Patch or Fentanyl(Transdermal) Patch for sale and Fentanyl Patch for sale
Precautions must also be taken in patients with the following conditions;
The concomitant use of Duragesic with potent cytochrome P450 3A4 inhibitors(ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazodone) may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. Patients receiving Duragesic and potent CYP3A4 inhibitors should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted. see wiki